A New Way of Exploring Immunity--Linking Highly Multiplexed Antigen Recognition to Immune Repertoire and Phenotype

A New Way of Exploring Immunity–Linking Highly Multiplexed Antigen Recognition to Immune Repertoire and Phenotype

We demonstrate the power of the Single Cell Immune Profiling Solution with Feature Barcoding technology to:

• Assess the binding specificities of over 150,000 CD8+ T cells from 4 human donors across a highly multiplexed panel of 44 distinct, specific peptide–MHC (pMHC) multimers

• Uncover data at single cell resolution for gene and cell surface protein expression, TCR-pMHC binding specificity, and paired aß T-cell receptor (TCR) sequences

• Generate highly multiplexed binding data from many different pMHC multimers in a single experiment

• Enable the potential to develop novel experimental and analytical approaches

• Help facilitate a greater understanding of how the adaptive immune system responds to immune insults and contribute to the development of therapeutics

w defa610 - A New Way of Exploring Immunity--Linking Highly Multiplexed Antigen Recognition to Immune Repertoire and Phenotype

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